Surface receptor-induced apoptosis in trasformed cells: defining the molecular events involved in TNFR-1 and Fas/APO-1 -induced apoptotic signaling

The Partnership

The Objectives

The goal of this project is to characterize the molecular pathways bringing the signals generated from the human TNF-R1 and Fas/APO-1 receptors down to the effectors of the apoptotic response in tumor cells.