Dottorato di ricerca in Biotecnologie Mediche e Medicina Molecolare

Informazioni generali

Denominazione del corso	Biotecnologie Mediche e Medicina Molecolare
Durata prevista	3 ANNI
Dipartimento	Dip. MEDICINA INTERNA

Ambito

Settori scientifico disciplinari interessati	Aree interessate
MED/03 - GENETICA MEDICA	06 - Scienze mediche
MED/05 - PATOLOGIA CLINICA	06 - Scienze mediche
MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA	06 - Scienze mediche
MED/09 - MEDICINA INTERNA	06 - Scienze mediche
BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA	05 - Scienze biologiche

Atenei italiani consorziati

Ateneo

Dipartimento/Facoltà

Sede dell'attività didattica

Atenei stranieri consorziati

Denominazione	Stato	Tipologia di Dottorato	Sede dell'attività didattica
Vrije Universiteit Dept. of Pharmacochemistry	NETHERLANDS	Con tesi in cotutela	NO
Lisbon University Dept. of Medical Sciences	POLAND	Con tesi in cotutela	NO

Convenzione con soggetti (enti/organizzazioni/istituzioni)

n.	Tipologia del soggetto	Denominazione del soggetto	Denominazione nuovo soggetto
1.	Ospedali/ASL		Azienda Universitaria Ospedaliera Policlinico Tor Vergata
2.	Fondazione		IRCCS Santa Lucia Roma
3.	Irccs		IRCCS Osp. Pediatrico Bambino Gesù Roma

Obiettivi formativi

Durante il Corso di dottorato, gli studenti acquisiranno una conoscenza approfondita degli aspetti biochimici e molecolari delle cellule eucariote e procariote al fine di mettere in atto colture cellulari di linee trasformate nonché colture cellulari primarie. Nello stesso tempo apprenderanno le biotecnologie cellulari e molecolari necessarie per la progettazione e la realizzazione di programmi di ricerca che abbiano una ricaduta clinica sia ai fini della produzione di biofarmaci e diagnostici, sia ai fini dellla comprensione di meccanismi fisiopatogenetici.
Verranno inoltre sviluppate conoscenze sulla struttura, funzione ed analisi delle macromolecole biologiche e dei processi cellulari nei quali esse intervengono nonché su metodologie bioinformatiche necessarie alla costruzione e all’accesso a banche dati e alla distribuzione di informazioni scientifiche attraverso tecniche elettroniche.
Saranno fornite agli studenti le conoscenze di base sulle patologie congenite ed acquisite nelle quali sia ipotizzabile un intervento di carattere biotecnologico cosiccome sulle patologie legate a problematiche microbiologiche ed ambientali comprensive di quelle legate all’alimentazione. Questo tipo di formazione dovrebbe permettere al Dottorando una cospicua interazione con la controparte clinica al fine di mettere appunto nuove strategie diagnostiche e terapeutiche.
Durante il Corso di dottorato verrà poi affrontata la problematica dell’impatto ambientale dei prodotti biotecnologici con lo scopo di prevenirne gli eventuali effetti nocivi.
Infine saranno approfondite le conoscenze relative alla Normativa Nazionale ed Europea relativa alla bietica, alla tutela delle invenzioni e alla sicurezza nel settore biotecnologico.

Tematiche di ricerca

1.	Studio di modello in vivo e in vitro dei processi di biotrasformazione e di tossicità
2.	Applicazioni della proteomica nello studio di neoplasie dell'infanzia e dell'adulto
3.	Applicazioni di biologia molecolare nell'ambito della farmacogenetica e dell'oncologia
4.	Applicazioni di biologia molecolare nell'ambito dello studio dell'espressione genica con metodiche RealTime PCR e microarrays.
5.	Utilizzo del phage display e del doppio ibrido nello studio delle interazioni proteina-proteina
6.	Nuove tecniche di preparazione di biochip e microarray in genomica e proteomica
7.	Identificazione di varianti genomiche in batteri e virus di interesse medico

Coordinatore responsabile

Cognome	FEDERICI
Nome	Giorgio
Ateneo	Università degli Studi di ROMA "Tor Vergata"
Dipartimento	Dip. MEDICINA INTERNA
Ruolo	Prof. ordinario
Settore	BIO/12

Partecipanti il collegio (personale di ruolo nelle università italiane)

n.	Cognome	Nome	Ateneo	Dipartimento	Ruolo	Settore
1.	BERNARDINI	Sergio	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	PA	BIO/12
2.	BOTTA	Annalisa	Università degli Studi di ROMA "Tor Vergata"	DIP. BIOPATOLOGIA E DIAGNOSTICA PER IMMAGINI	RU	MED/03
3.	CORTESE	Claudio	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	PO	BIO/12
4.	DESSI'	Maria Rita	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	RU	BIO/12
5.	FAVALLI	Cartesio	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA SPERIMENTALE E SCIENZE BIOCHIMICHE	PO	MED/07
6.	FEDERICI	Giorgio	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	PO	BIO/12
7.	FEDERICI	Massimo	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	PA	MED/09
8.	GRELLI	Sandro	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA SPERIMENTALE E SCIENZE BIOCHIMICHE	RU	MED/07
9.	LO BELLO	Mario	Università degli Studi di ROMA "Tor Vergata"	DIP. BIOLOGIA	PA	BIO/10
10.	LO COCO	Francesco	Università degli Studi di ROMA "Tor Vergata"	DIP. BIOPATOLOGIA E DIAGNOSTICA PER IMMAGINI	PA	MED/15
11.	PORZIO	Ottavia	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	RU	BIO/12
12.	SANGUIGNI	Valerio	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	RU	MED/09
13.	SANTORO	Luigi	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	RU	BIO/12
14.	ZENOBI	Rossella	Università degli Studi di ROMA "Tor Vergata"	DIP. MEDICINA INTERNA	RU	BIO/12
15.	ZINNO	Francesco	Università degli Studi di ROMA "Tor Vergata"	DIP. BIOPATOLOGIA E DIAGNOSTICA PER IMMAGINI	RU	MED/05

Personale appartenente ad Università Straniere

n.	Cognome	Nome	Struttura	Dipartimento	Ruolo	Settore
1.	Kranendok	Michel	Lisbon University	Genetics	Full Professor	Genetics
2.	Vermeulen	Nico	Vrije Universiteit	Pharmacochemistry	Full Professor	Tossicology

Partecipanti il collegio (personale non di ruolo nelle università o dipendente di altri enti)

n.	Cognome	Nome	Struttura	Dipartimento	Ruolo	Settore
1.	Barbetti	Fabrizio	IRCCS Bambino Gesù Roma	Endocrinology	ricercatore
2.	Pastore	Anna	IRCCS Bambino Gesù Roma	Protein Chemistry	ricercatore	Biochimica
3.	Piemonte	Fiorella	IRCCS Bambino Gesù Roma	Neurochemistry	ricercatore

Requisiti richiesti per l'ammissione

VECCHIO ORDINAMENTO: Tutte le lauree	SI
Se non tutte consentono l'accesso, indicare quelle che lo consentono
NUOVO ORDINAMENTO: Tutte le lauree	SI
Se non tutte consentono l'accesso, indicare quelle che lo consentono
Altro per studenti stranieri	Colloquio e titoli
Altro

Modalità di ammissione

Analisi titoli,
Prova scritta,
Orale

Per i candidati stranieri (se diversa da quella per i candidati italiani)

Attività

Attività didattica prevista	SI	Obbligatorio
-Insegnamenti previsti nell'iter formativo	tot CFU  120	n.ro insegnamenti  12
-Insegnamenti mutuati da corsi di laurea	NO	n.ro
Cicli seminariali	SI	n.ro  12
Verifiche annuali previste	SI	n.ro  1
Numero totale delle verifiche	3
Stage presso	Istituzione scientifica straniera, Irccs, Ospedali/ASL
Soggiorni all'estero	SI	Non Obbligatorio
-Periodo consentito all'estero (in mesi)	min:  1	max:  18
-Finalità del soggiorno all'estero	Frequenza corsi, Attività di ricerca, Attività relative alla tesi

Produzione scientifica del collegio dal 1999 al 2004 (personale di ruolo nelle università italiane)

1.	AMATI F., CONTI E., BOTTA A., AMICUCCI P., DALLAPICCOLA B., NOVELLI G. (2001). Functional characterisation of the 5' flanking region of human Ubiquitin Fusion Degradation 1 Like gene (UFD1L). CELL BIOCHEMISTRY AND FUNCTION. vol. 20, pp. 163-170.
2.	BALLERINI S, BELLINCAMPI L, BERNARDINI S, CASCIANI S, MOTTI C, CORTESE C, FEDERICI G. (2002). Apolipoprotein E genotyping: a comparative study between restriction endonuclease mapping and allelic discrimination with the LightCycler. CLINICA CHIMICA ACTA. vol. 317, pp. 71-76.
3.	BALLERINI S, BELLINCAMPI L, BERNARDINI S, CASCIANI S, MOTTI C, CORTESE C., FEDERICI G. (2002). Apolipoprotein E genotyping: a comparative study between restriction endonuclease mapping and allelic discrimination with the LightCycler. CLINICA CHIMICA ACTA. vol. 317(1-2), pp. 71-6.
4.	BALLERINI S, BELLINCAMPI L, BERNARDINI S, IORI R, CORTESE C, FEDERICI G. (2003). Analysis of GSTP1-1 polymorphism using real-time polymerase chain reaction. Clin Chim Acta. 2003 Mar;329(1-2):127-32. CLINICA CHIMICA ACTA. vol. 329, pp. 127-132.
5.	BALLERINI S, BELLINCAMPI L, BERNARDINI S, IORI R, CORTESE C., FEDERICI G. (2003). Analysis of GSTP1-1 polymorphism using real-time polymerase chain reaction. CLINICA CHIMICA ACTA. vol. 329, pp. 127-132.
6.	BALLERINI S, BELLINCAMPI L, BERNARDINI S., CASCIANI S, MOTTI C, CORTESE C, FEDERICI G. (2002). The apolipoprotein E genotyping: a comparative studybetween restriction endonuclease mapping and allelic discrimination with the Light Cycler. CHIMICA CLINICA ACTA. vol. 317, pp. 71-76.
7.	BALLERINI S, BELLINCAMPI L, BERNARDINI S., IORI R, CORTESE C, FEDERICI G. (2003). Analysis of GSTP1 polymorphism using real time polymerase chain reaction. CLINICA CHIMICA ACTA. vol. 329, pp. 127-132.
8.	BELLINCAMPI L, BALLERINI S, BERNARDINI S., INSERRA A, MARCHETTI P, BOGLINO C, DONFRANCESCO A, FEDERICI G. (2001). Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 39, pp. 830-835.
9.	BELLINCAMPI L, SIMONE ML, MOTTI C, CORTESE C, BERNARDINI S., BERTOLINI S, CALANDRA S. (2001). Identification of an alternative transcript of ABCA1 gene in different cell types. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 283, pp. 590-597.
10.	BELLINCAMPI L, SIMONE ML, MOTTI C, CORTESE C., BERNARDINI S, BERTOLINI S, CALANDRA S. (2001). Identification of an alternative transcript of ABCA1 gene in different human cell types. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. vol. 283, pp. 590-7 ISSN: 0006-291X .
11.	BELLINCAMPI L., BALLERINI S., BERNARDINI S., INSERRA A., MARCHETTI P., BOGLINO C., DONFRANCESCO A., FEDERICI G. (2001). Glutathione transferasi P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 39, pp. 830-835.
12.	BERNARDINI S, BELLINCAMPI L, BALLERINI S, RANALLI M, PASTORE A, CORTESE C, FEDERICI G. (2002). Role of GST P1-1 in mediating the effect of etoposide on human neuroblastoma cell line Sh-Sy5y. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 86, pp. 340-347.
13.	BERNARDINI S, BELLINCAMPI L, BALLERINI S, RANALLI M, PASTORE A, CORTESE C., FEDERICI G. (2002). Role of GSTP1-1 in mediating the effect of etoposide on human neuroblastoma cell line Sh-Sy5y. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 86, pp. 340-347.
14.	BERNARDINI S, INFANTINO M, BELLINCAMPI L, NUCCETELLI M, AFELTRA A, LORI R, BIROCCIO A, URBANI A, FEDERICI G. (2004). Screening of antinuclear antibodies: comparison between enzyme immunoassay based on nuclear homogenates, purified or recombinant antigens and immunofluorescence assay. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 42, pp. 1155-1160.
15.	BERNARDINI S, MIANO R, IORI R, FINAZZI-AGRO E, PALMIERI G, BALLERINI S, ANGELONI C, ORLANDI A, BELLINCAMPI L, CORTESE C, FEDERICI G. (2004). Hypermethylation of the CpG islands in the promoter region of the GSTP1 gene in prostate cancer: a useful diagnostic and prognostic marker?. CLINICA CHIMICA ACTA. vol. 350, pp. 181-188.
16.	BERNARDINI S., BELLINCAMPI L, BALLERINI S, RANALLI M, PASTORE A, CORTESE C, FEDERICI G. (2002). Role of GSTP1-1 in mediating the effect of etoposide on human neuroblastoma cell line SH-SY5Y. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 86, pp. 340-347.
17.	BERNARDINI S., BERNASSOLA F, CORTESE C, BALLERINI S, MELINO G, MOTTI C, BELLINCAMPI L, IORI R, FEDERICI G. (2000). Modulation of GSTP1-1 activity and polimerization during apoptosis. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 77, pp. 645-653.
18.	BERNARDINI S., BERNASSOLA F., CORTESE C., BALLERINI S., FEDERICI G. (2000). Modulation of GST P11 activity by polimerization during apoptosis. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 77, pp. 645-653.
19.	BERNARDINI S., INFANTINO M, NUCCETELLI M, BELLINCAMPI L, AFELTRA A, IORI R, BIROCCIO A, URBANI A, FEDERICI G. (2004). Antinuclear antibodies screening: comparison between enzyme immunoassay based on nuclear homogenates, purified or recombinant antigens and immunofluorescence assay. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 42, pp. 1155-1160.
20.	BERNARDINI S., MELII G., CORTESE C., BALLERINI S., FEDERICI G. (1999). Modulation of glutathione transferase P1-1 activity by retinoic acid in neuroblastoma cells. JOURNAL OF CELLULAR BIOCHEMISTRY. vol. 75, pp. 375-381.
21.	BERNARDINI S., MIANO R, IORI R, FINAZZI-AGR E, PALMIERI G, BALLERINI S, ANGELONI C, ORLANDI A, BELLINCAMPI L, CORTESE C, FEDERICI G. (2004). Hypermethylation of the CpG islands in the promoter region of the GSTP1 gene in prostate cancer: a useful diagnostic and prognostic marker ?. CHIMICA CLINICA ACTA. vol. 350, pp. 181-188.
22.	BERNASSOLA F, FEDERICI M., CORAZZARI M, TERRINONI A, HRIBAL ML, DE LAURENZI V, RANALLI M, MASSA O, SESTI G, MACLEAN H, BARBETTI F, MELINO G. (2002). Role of transglutaminase 2 in glucose tolerance: knockout mice studies and a putative mutation in a MODY patient. FASEB JOURNAL. vol. 16, pp. 1371-1378.
23.	BONIFAZI E., VALLO L., GIARDINA E., BOTTA A., NOVELLI G. (2004). A long PCR-based molecular protocol for detecting normal and expanded alleles in myotonic dystrophy type 2. DIAGNOSTIC MOLECULAR PATHOLOGY. vol. 13, pp. 164-166.
24.	BORBONI P, PORZIO O., PIERUCCI D, CICCONI S, MAGNATERRA R, FEDERICI M, SESTI, G, LAURO D, D'AGATA V, CAVALLARO S, MARLIER LN. (1999). Molecular and functional characterization of pituitary adenylate cyclase-activating polypeptide (PACAP-38)/vasoactive intestinal polypeptide receptors in pancreatic beta-cells and effects of PACAP-38 on components of the insulin secretory system. ENDOCRINOLOGY. vol. 140, pp. 5530-5537.
25.	BOTTA A., AMATI F, NOVELLI G. (2001). Causes of the phenotype-genotype dissociation in DiGeorge syndrome: clues from mouse models. TRENDS IN GENETICS. vol. 17, pp. 551-554.
26.	BOTTA A., TANDOI C., FINI G., CALABRESE G., DALLAPICCOLA B., NOVELLI G. (2001). Cloning and charactherization of the gene NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L). GENE. vol. 275, pp. 39-46.
27.	C. MICALONI, A.P. MAZZETTI, M. NUCCETELLI, J. ROSSJOHN, W.J. MCKINSTRY, G. ANTONINI, A.M. CACCURI, A.J. OAKLEY, G. FEDERICI, G. RICCI, M.W. PARKER, LO BELLO M. (2000). valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1. BIOCHEMISTRY. vol. 39, pp. 15961-15970.
28.	C. MICALONI, K.W. KONG, A.P. MAZZETTI, M. NUCCETELLI, G. ANTONINI, L. STELLA, W.J. MCKINSTRY, J. ROSSJOHN, G.FEDERICI, G. RICCI, M.W. PARKER, LO BELLO M. (2003). Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. JOURNAL OF MOLECULAR BIOLOGY. vol. 325, pp. 111-122.
29.	C. TANDOI, BOTTA A., G. FINI, F. SANGIUOLO, R. RICCI, G. ZAMPINO, C. ANICHINI, B. DALLAPICCOLA, G. NOVELLI. (2001). Exclusion of the Elastin Gene in the Pathogenesis of Costello Sindrome. AMERICAN JOURNAL OF MEDICAL GENETICS. vol. 98, pp. 286-287.
30.	CACCESE D, PRATICO D, GHISELLI A, NATOLI S, PIGNATELLI P, SANGUIGNI V., IULIANO L, VIOLI F. (2000). Superoxide anion and hydroxyl radical release by collagen-induced platelet aggregation--role of arachidonic acid metabolism. THROMBOSIS AND HAEMOSTASIS. vol. 83, pp. 485-490.
31.	CACCURI A.M., ANTONINI G., PARKER M.W., FEDERICI G., RICCI G. (1999). Proton release on binding of glutathione to alpha, Mu and delta class of gluathione transferase. BIOCHEMICAL JOURNAL. vol. 344, pp. 419-425.
32.	CACCURI AM, ANTONINI G, ALLOCATI N, DI ILIO C, DE MARIA F, INNOCENTI F, PARKER MW, MASULLI M, LO BELLO M, TURELLA P, FEDERICI G., RICCI G. (2002). GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 277, pp. 18777-18784.
33.	CACCURI AM, ANTONINI G, ALLOCATI N, DI ILIO C, INNOCENTI F, DE MARIA F, PARKER MW, MASULLI M, POLIZIO F, FEDERICI G., RICCI G. (2002). Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1. BIOCHEMISTRY. vol. 41, pp. 4686-4693.
34.	CACCURI AM, ANTONINI G, ASCENZI P, NICOTRA M, NUCCETELLI M, MAZZETTI AP, FEDERICI G., LO BELLO M, RICCI G. (1999). Temperature adaptation of glutathione S-transferase P1-1. A case for homotropic regulation of substrate binding. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 274, pp. 19276-19280.
35.	CACCURI AM, ANTONINI G, BOARD PG, FLANAGAN J, PARKER MW, PAOLESSE R, TURELLA P, FEDERICI G., LO BELLO M, RICCI G. (2001). Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 276, pp. 5427-5431.
36.	CACCURI AM, ANTONINI G, BOARD PG, PARKER MW, NICOTRA M, LO BELLO M, FEDERICI G., RICCI G. (1999). Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases. BIOCHEMICAL JOURNAL. vol. 344, pp. 419-425.
37.	CAPPA M, BIZZARRI C, MARTINEZ C, PORZIO O., GIANNONE G, TURCHETTA A, CALZOLARI A. (2000). Neuroregulation of growth hormone during exercise in children. INTERNATIONAL JOURNAL OF SPORTS MEDICINE. vol. 21, pp. 125-128.
38.	CAPPA M, RIGAMONTI AE, BIZZARRI C, PORZIO O., CIVOLANI P, CELLA SG, LOCHE S, MULLER EE. (1999). Somatostatin infusion withdrawal: studies in normal children and in children with growth hormone deficiency. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. vol. 84, pp. 4426-4430.
39.	CARRABS T, DI RUSSA G, VELLINI MC, PIETROIUSTI A, NOVELLI GP, SILVESTRINI M, RIZZATO B, DIOMEDI M, FONTANA C, FAVALLI C., GALANTE A. (2001). Infezione da Chlamydia pneumoniae e Helicobacter pylori e spessore miointimale in pazienti con evento cerebrovascolare acuto. 102 Congresso della Società Italiana di Medicina Interna. 23-26 Ottobre.
40.	CASETTA B, TAGLIACOZZI D, SHUSHAN B, FEDERICI G. (2000). Development of a method for rapid quantitation of amino acids by liquid chromatography-tandem mass spectrometry (LC-MSMS) in plasma. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 38, pp. 391-401.
41.	CASETTA B., TAGLIACOZZI D., SHUSHAN B., FEDERICI G. (2000). Development of a method for a rapid quantitation of aminoacids by liquid chromatography-tandem mass spectrometry (LC-MS-MS) in plasma. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 38, pp. 391-401.
42.	CHESON B., BENNET JM., KOPECKY KJ., BUCHNER T., WILLMAN CL., ESTEY E., SCHIFFER CA., DOEHNER H., TALLMAN MS., LISTER TA., LO COCO F., ET AL. (2003). Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. JOURNAL OF CLINICAL ONCOLOGY. vol. 21, pp. 4642-4649.
43.	CORTESE C., CORONA R. (2003). Takimg advantage of a side effect of isotretinoin. ARCHIVES OF DERMATOLOGY. vol. 139, pp. 376-377.
44.	CORTESE C., MOTTI C. (2001). MTHFR gene polymorphism, homocysteine and cardiovascular disease. PUBLIC HEALTH NUTRITION. vol. 4, pp. 493-497.
45.	D'ALFONSO R, MARINI MA, FRITTITTA L, SORGE R, FRONTONI S, PORZIO O., MARIANI, LM, LAURO D, GAMBARDELLA S, TRISCHITTA V, FEDERICI M, LAURO R, SESTI G. (2003). Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. vol. 88, pp. 317-322.
46.	DE LUCA A., PASINI A., AMATI F., BOTTA A., SPALLETTA G., ALIMENTI S., CACCAMO F., CONTI E., TRAKALO J., MACCIARDI F., DALLAPICCOLA B., NOVELLI G. (2001). Association study of a promoter polymorphism of UFD1L gene with schizophrenia. AMERICAN JOURNAL OF MEDICAL GENETICS. vol. 105, pp. 529-533.
47.	DE MARIA F, PEDERSEN JZ, CACCURI AM, ANTONINI G, TURELLA P, STELLA L, LO, BELLO M, FEDERICI G., RICCI G. (2003). The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 278, pp. 42283-42293.
48.	DE MARIA, F., PEDERSEN JZ., CACCURI, AM., ANTONINI, G., TURELLA P.STELLA L., LO BELLO M., FEDERICI G., RICCI G. (2003). The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO-carrier, withe glutathione transferase superfamily. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 276, pp. 42283-42293.
49.	DELLO STROLOGO L, CAMPAGNANO P, FEDERICI G., RIZZONI G. (1999). Cyclosporine A monitoring in children: abbreviated area under curve formulas and C2 level. PEDIATRIC NEPHROLOGY. vol. 13, pp. 95-97.
50.	DELLO STROLOGO L, PONTESILLI C, MONTINI G, GINEVRI F, ARDISSINO G, CAMPAGNANO P, PASTORE A, FEDERICI G., RIZZONI G. (2001). Renal hemodynamic effect of tacrolimus in renal transplanted children. PEDIATRIC NEPHROLOGY. vol. 16, pp. 773-776.
51.	DESSI M, GNASSO A, MOTTI C, PUJIA A, IRACE C, CASCIANI S, STAFFA F, CORTESE C. (1999). Influence of the human paraoxonase gene polymorphism (PON 1) on the carotid wall thickening in a healthy population. CORONARY HEART DISEASE. vol. 10(8), pp. 595/99 ISSN: 0954/6928 .
52.	DESSI M, GNASSO A, MOTTI C, PUJIA A, IRACE C, CASCIANI S, STAFFA F, FEDERICI G., CORTESE C. (1999). Influence of the human paraoxonase polymorphism (PON1 192) on the carotid-wall thickening in a healthy population. CORONARY ARTERY DISEASE. vol. 10, pp. 595-599.
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128.	RATTI A., AMATI F., BOZZALI M., CONTI E., SANGIUOLO F., BERLOCO M., PALUMBO G., BOTTA A., PIZZUTI A., NOVELLI G., DALLAPICCOLA B. (2001). Cloning and molecular characterization of three Ubiquitin Fusion Degradation 1 (Ufd1) ortholog genes from X. laevis, G. gallus and D. melanogaster. CYTOGENETICS AND CELL GENETICS. vol. 92, pp. 279-282.
129.	RICCI G, CACCURI AM, LO BELLO M, PARKER MW, NUCCETELLI M, TURELLA P, STELLA, L, DI IORIO EE, FEDERICI G. (2003). Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. BIOCHEMICAL JOURNAL. vol. 376, pp. 71-76.
130.	RICCI G, TURELLA P, DE MARIA F, ANTONINI G, NARDOCCI L, BOARD PG, PARKER MW, CARBONELLI MG, FEDERICI G., CACCURI AM. (2004). Binding and kinetic mechanisms of the Zeta class glutathione transferase. JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 279, pp. 33336-33342.
131.	RIZZO C, BERTINI E, PIEMONTE F, LEUZZI V, SABETTA G, FEDERICI G., LUCHETTI, A, DIONISI-VICI C. (2000). Oxidative abnormalities in Menkes disease. JOURNAL OF INHERITED METABOLIC DISEASE. vol. 23, pp. 349-351.
132.	RIZZO C, DIONISI-VICI C, D'IPPOLITI M, FINA F, SABETTA G, FEDERICI G. (2000). A simple and rapid HPLC method for simultaneous determination of plasma 7-dehydrocholesterol and vitamin E: its application in Smith-Lemli-Opitz patients. CLINICA CHIMICA ACTA. vol. 291, pp. 97-102.
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134.	SANGUIGNI V., PIGNATELLI P, CACCESE D, PULCINELLI FM, LENTI L, MAGNATERRA R, MARTINI F, LAURO R, VIOLI F. (2002). Increased superoxide anion production by platelets in hypercholesterolemic patients. THROMBOSIS AND HAEMOSTASIS. vol. 87, pp. 796-801.
135.	SEMPRINI S., CAPON F., TACCONELLI A., GIARDINA E., ORECCHIA A., MINGARELLI R., GABELLO T., ZAMBRUNO G., BOTTA A., FABRIZI G., NOVELLI G. (2002). Evidence for differential S100 over-expression in psoriatic patients from genetically heterogeneous pedigrees. HUMAN GENETICS. vol. 111, pp. 310-313.
136.	SESTI G, FEDERICI M., HRIBAL M, LAURO D, SBRACCIA P, LAURO R. (2001). Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB JOURNAL. vol. 15, pp. 2099-111.
137.	SPLENDIANI G, DE ANGELIS S, TULLIO T, FERRANINI M, DESSI MR, PASTORE A, CASCIANI S, LIBERATOSCIOLI L, FEDERICI G., CORTESE C. (2004). Selective adsorption of homocysteine using an HFR-ON LINE technique. ARTIFICIAL ORGANS. vol. 28, pp. 592-595.
138.	TAGLIACOZZI D, MOZZI A, CASETTA B, BERTUCCI P, BERNARDINI S., DI ILIO C, URBANI A, FEDERICI G. (2003). Quantitative analysis of bile acids in human plasma by liquid cromatography-elettrospray tandem mass-spectrometry. CLINICAL CHEMISTRY LABORATORY MEDICINE. vol. 41, pp. 1633-1641.
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Produzione scientifica del collegio dal 1999 al 2004 (personale non di ruolo nelle università o dipendenti di altri enti)

1: Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur
JN.
Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and
regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.
Biochem Pharmacol. 2004 Dec 1;68(11):2263-71.
PMID: 15498516 [PubMed - in process]

2: Dijksterhuis A, Corneille O, Aarts H, Vermeulen N, Luminet O.
Yes, there is a preferential detection of negative stimuli. A response to
Labiouse.
Psychol Sci. 2004 Aug;15(8):571-2. No abstract available.
PMID: 15271004 [PubMed - indexed for MEDLINE]

3: Yenes S, Commandeur JN, Vermeulen NP, Messeguer A.
In vitro biotransformation of
3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent
lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver
microsomes.
Chem Res Toxicol. 2004 Jul;17(7):904-13.
PMID: 15257615 [PubMed - indexed for MEDLINE]

4: Orhan H, Commandeur JN, Sahin G, Aypar U, Sahin A, Vermeulen NP.
Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture
detection in the quantitative analysis of fluorine-containing metabolites in
urine of sevoflurane-anaesthetized patients.
Xenobiotica. 2004 Mar;34(3):301-16.
PMID: 15204701 [PubMed - indexed for MEDLINE]

5: Onderwater RC, Commandeur JN, Vermeulen NP.
Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in
precision-cut rat liver slices.
Toxicology. 2004 Apr 15;197(2):81-91.
PMID: 15003319 [PubMed - indexed for MEDLINE]

6: Rooseboom M, Commandeur JN, Vermeulen NP.
Enzyme-catalyzed activation of anticancer prodrugs.
Pharmacol Rev. 2004 Mar;56(1):53-102. Review.
PMID: 15001663 [PubMed - indexed for MEDLINE]

7: van Lipzig MM, ter Laak AM, Jongejan A, Vermeulen NP, Wamelink M, Geerke D,
Meerman JH.
Prediction of ligand binding affinity and orientation of xenoestrogens to the
estrogen receptor by molecular dynamics simulations and the linear interaction
energy method.
J Med Chem. 2004 Feb 12;47(4):1018-30.
PMID: 14761204 [PubMed - indexed for MEDLINE]

8: Orhan H, Vermeulen NP, Tump C, Zappey H, Meerman JH.
Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine
oxidation products by liquid chromatography-tandem mass spectrometry as
non-invasive biomarkers for oxidative damage.
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Jan 25;799(2):245-54.
PMID: 14670743 [PubMed - indexed for MEDLINE]

9: Venhorst J, ter Laak AM, Meijer M, van de Wetering I, Commandeur JN,
Rooseboom M, Vermeulen NP.
Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate
beta-lyase.
J Mol Graph Model. 2003 Sep;22(1):55-70.
PMID: 12798391 [PubMed - indexed for MEDLINE]

10: Vermeulen NP.
Prediction of drug metabolism: the case of cytochrome P450 2D6.
Curr Top Med Chem. 2003;3(11):1227-39. Review.
PMID: 12769702 [PubMed - indexed for MEDLINE]

11: Venhorst J, Rooseboom M, Vermeulen NP, Commandeur JN.
Studies on the inhibition of human cytochromes P450 by selenocysteine
Se-conjugates.
Xenobiotica. 2003 Jan;33(1):57-72.
PMID: 12519694 [PubMed - indexed for MEDLINE]

12: 't Hoen PA, Out R, Commandeur JN, Vermeulen NP, van Batenburg FH, Manoharan
M, van Berkel TJ, Biessen EA, Bijsterbosch MK.
Selection of antisense oligodeoxynucleotides against glutathione S-transferase
Mu.
RNA. 2002 Dec;8(12):1572-83.
PMID: 12515389 [PubMed - indexed for MEDLINE]

13: Venhorst J, ter Laak AM, Commandeur JN, Funae Y, Hiroi T, Vermeulen NP.
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and
computational rationalization of experimental ligand-binding specificities.
J Med Chem. 2003 Jan 2;46(1):74-86.
PMID: 12502361 [PubMed - indexed for MEDLINE]

14: Rooseboom M, Vermeulen NP, Durgut F, Commandeur JN.
Comparative study on the bioactivation mechanisms and cytotoxicity of
Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and
S-phenyl-L-cysteine.
Chem Res Toxicol. 2002 Dec;15(12):1610-8.
PMID: 12482244 [PubMed - indexed for MEDLINE]

15: Kutyavin IV, Lokhov SG, Afonina IA, Dempcy R, Gall AA, Gorn VV, Lukhtanov
E, Metcalf M, Mills A, Reed MW, Sanders S, Shishkina I, Vermeulen NM.
Reduced aggregation and improved specificity of G-rich
oligodeoxyribonucleotides containing pyrazolo[3,4-d]pyrimidine guanine bases.
Nucleic Acids Res. 2002 Nov 15;30(22):4952-9.
PMID: 12433999 [PubMed - indexed for MEDLINE]

16: Rooseboom M, Vermeulen NP, Groot EJ, Commandeur JN.
Tissue distribution of cytosolic beta-elimination reactions of selenocysteine
Se-conjugates in rat and human.
Chem Biol Interact. 2002 Aug 15;140(3):243-64.
PMID: 12204580 [PubMed - indexed for MEDLINE]

17: 't Hoen PA, Rooseboom M, Bijsterbosch MK, van Berkel TJ, Vermeulen NP,
Commandeur JN.
Induction of glutathione-S-transferase mRNA levels by chemopreventive
selenocysteine Se-conjugates.
Biochem Pharmacol. 2002 May 15;63(10):1843-9.
PMID: 12034368 [PubMed - indexed for MEDLINE]

18: 't Hoen PA, Rosema BS, Commandeur JN, Vermeulen NP, Manoharan M, van Berkel
TJ, Biessen EA, Bijsterbosch MK.
Selection of effective antisense oligodeoxynucleotides with a green fluorescent
protein-based assay. Discovery of selective and potent inhibitors of glutathione
S-transferase Mu expression.
Eur J Biochem. 2002 May;269(10):2574-83.
PMID: 12027896 [PubMed - indexed for MEDLINE]

19: Rooseboom M, Schaaf G, Commandeur JN, Vermeulen NP, Fink-Gremmels J.
Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by
selenocysteine Se-conjugates in renal tubular cell lines.
J Pharmacol Exp Ther. 2002 Jun;301(3):884-92.
PMID: 12023515 [PubMed - indexed for MEDLINE]

20: Rooseboom M, Vermeulen NP, Commandeur JN.
Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se
conjugates.
Methods Enzymol. 2002;348:191-200. No abstract available.
PMID: 11885272 [PubMed - indexed for MEDLINE]1: Garcia-Ruiz JM, Hyde ST, 21)

21)Carnerup AM, Christy AG, Van Kranendonk MJ, Welham
NJ.
Self-assembled silica-carbonate structures and detection of ancient
microfossils.
Science. 2003 Nov 14;302(5648):1194-7.
PMID: 14615534 [PubMed - indexed for MEDLINE]

22: Rueff J, Gaspar J, Kranendonk M.
DNA polymorphisms as modulators of genotoxicity and cancer.
Biol Chem. 2002 Jun;383(6):923-32. Review.
PMID: 12222682 [PubMed - indexed for MEDLINE]

23: Brasier MD, Green OR, Jephcoat AP, Kleppe AK, Van Kranendonk MJ, Lindsay JF,
Steele A, Grassineau NV.
Questioning the evidence for Earth's oldest fossils.
Nature. 2002 Mar 7;416(6876):76-81.
PMID: 11882895 [PubMed - indexed for MEDLINE]

24: Kranendonk M, Laires A, Rueff J, Estabrook WR, Vermeulen NP.
Heterologous expression of xenobiotic mammalian-metabolizing enzymes in
mutagenicity tester bacteria: an update and practical considerations.
Crit Rev Toxicol. 2000 May;30(3):287-306. Review.
PMID: 10852498 [PubMed - indexed for MEDLINE]

25: Kranendonk M, Carreira F, Theisen P, Laires A, Fisher CW, Rueff J, Estabrook
RW, Vermeulen NP.
Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity
tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2,
2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.
Mutat Res. 1999 Apr 26;441(1):73-83.
PMID: 10224324 [PubMed - indexed for MEDLINE]

26: Kranendonk M, Fisher CW, Roda R, Carreira F, Theisen P, Laires A, Rueff J,
Vermeulen NP, Estabrook RW.
Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity
tester strain for the expression of human cytochrome P450: comparison of three
types of expression systems.
Mutat Res. 1999 Feb 19;439(2):287-300.

27: Ferreirinha F, Quattrini A, Pirozzi M, Valsecchi V, Dina G, Broccoli V,
Auricchio A, Piemonte F, Tozzi G, Gaeta L, Casari G, Ballabio A, Rugarli EI.
Axonal degeneration in paraplegin-deficient mice is associated with abnormal
mitochondria and impairment of axonal transport.
J Clin Invest. 2004 Jan;113(2):231-42.
PMID: 14722615 [PubMed - indexed for MEDLINE]

28: Petruzzella V, Di Giacinto G, Scacco S, Piemonte F, Torraco A, Carrozzo R,
Vergari R, Dionisi-Vici C, Longo D, Tessa A, Papa S, Bertini E.
Atypical Leigh syndrome associated with the D393N mutation in the mitochondrial
ND5 subunit.
Neurology. 2003 Oct 14;61(7):1017-8. No abstract available.
PMID: 14557590 [PubMed - indexed for MEDLINE]

29: Pastore A, Tozzi G, Gaeta LM, Bertini E, Serafini V, Di Cesare S, Bonetto V,
Casoni F, Carrozzo R, Federici G, Piemonte F.
Actin glutathionylation increases in fibroblasts of patients with Friedreich's
ataxia: a potential role in the pathogenesis of the disease.
J Biol Chem. 2003 Oct 24;278(43):42588-95. Epub 2003 Aug 11.
PMID: 12915401 [PubMed - indexed for MEDLINE]

30: Pastore A, Federici G, Bertini E, Piemonte F.
Analysis of glutathione: implication in redox and detoxification.
Clin Chim Acta. 2003 Jul 1;333(1):19-39. Review.
PMID: 12809732 [PubMed - indexed for MEDLINE]

31: Pastore A, Tozzi G, Gaeta LM, Giannotti A, Bertini E, Federici G, Digilio
MC, Piemonte F.
Glutathione metabolism and antioxidant enzymes in children with Down syndrome.
J Pediatr. 2003 May;142(5):583-5.
PMID: 12756395 [PubMed - indexed for MEDLINE]

32: Pastore A, Francesca Mozzi A, Tozzi G, Maria Gaeta L, Federici G, Bertini E,
Lo Russo A, Mannucci L, Piemonte F.
Determination of glutathionyl-hemoglobin in human erythrocytes by
cation-exchange high-performance liquid chromatography.
Anal Biochem. 2003 Jan 15;312(2):85-90.
PMID: 12531191 [PubMed - indexed for MEDLINE]

33: Siciliano G, Monzani F, Manca ML, Tessa A, Caraccio N, Tozzi G, Piemonte F,
Mancuso M, Santorelli FM, Ferrannini E, Murri L.
Human mitochondrial transcription factor A reduction and mitochondrial
dysfunction in Hashimoto's hypothyroid myopathy.
Mol Med. 2002 Jun;8(6):326-33.
PMID: 12428064 [PubMed - indexed for MEDLINE]

34: Pastore A, Lo Russo A, Piemonte F, Mannucci L, Federici G.
Rapid determination of mycophenolic acid in plasma b...

.