Recent papers

Recent Publications

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De Maria, R., S. Fais, M. Silvestri, L. Frati, F. Pallone, A. Santoni and R. Testi. 1993. Continuous in vivo activation and transient hyporesponsiveness to TcR/CD3 triggering of human gut lamina propria lymphocytes. European Journal of Immunology 23:3104-3108. (abstract)

D'Ambrosio, D., R. Trotta, A. Vacca, L. Frati, A. Santoni, A. Gulino and R. Testi. 1993. Transcriptional regulation of interleukin 2 gene expression by CD69 generated signals. European Journal of Immunology 23:2993-2997. (abstract)

D'Ambrosio, D., D. A. Cantrell, L. Frati, A. Santoni and R. Testi. 1994. Involvement of p21ras in T cell CD69 expression. European Journal of Immunology 24:616-620. (abstract)

Cifone, M.G., R. De Maria, P. Roncaioli, M.R. Rippo, M. Azuma, L.L. Lanier, A. Santoni and R. Testi. 1994. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. Journal of Experimental Medicine 180:1547-1552. (abstract)

De Maria, R., M.G. Cifone, R. Trotta, M.R. Rippo, C. Festuccia, A. Santoni and R. Testi. 1994. Triggering of human monocyte activation through CD69, a member of the Natural Killer cell gene Complex (NKC) family of signal transducing receptors. Journal of Experimental Medicine 180:1999-2004. (abstract)

Testi, R., D. D'Ambrosio, R. De Maria and A. Santoni. 1994. The CD69 receptor: a multipurpose trigger for hematopoietic cells. Immunology Today 15:479-483. (abstract)

Cifone, M.G., L. Cironi, A. Santoni and R. Testi. 1995. Diacylglycerol lipase activation and 5-lipoxygenase activation and translocation following TCR/CD3 triggering in T cells. European Journal of Immunology 25:1080-1086. (abstract)

Giordano C., R. De Maria, G. Stassi, M. Todaro, P. Richiusa, M. Giordano, R. Testi and A. Galluzzo. 1995. Defective expression of the apoptosis-inducing CD95 (Fas/APO-1) molecule on T and B cells in IDDM. Diabetologia 38:1449-1454. (abstract)

Cifone, M.G., P. Roncaioli, R. De Maria, G. Camarda, A. Santoni, G. Ruberti and R. Testi. 1995. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO Journal14:5859-5868. (abstract).

De Maria R., M. Boirivant, M.G. Cifone, P. Roncaioli, M. Hahne, J. Tschopp, F. Pallone, A. Santoni and R. Testi. 1996. Functional expression of Fas and Fas Ligand on human gut lamina propria lymhocytes: a potential role for the acidic sphingomyelinase pathway in normal immunoregulation. Journal of Clinical Investigation 97:316-322. (abstract).

Cascino, I., G. Papoff, R. De Maria, R. Testi and G. Ruberti. 1996. Fas/APO-1/CD95 lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis. Journal of Immunology. 156:13-17. (abstract).

Boirivant, M., R. Pica, R. De Maria, R. Testi, F. Pallone and W. Strober. 1996. Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis. Journal of Clinical Investigation 98:2616-2622. (abstract).

Sallusto, F., C. Nicolo', R. De Maria, S. Corinti and R. Testi. 1996. Ceramide inhibits antigen uptake and presentation by dendritic cells. Journal of Experimental Medicine 184:2411-2416. (abstract).

Testi, R. 1996. Sphingomyelin breakdown and cell fate. Trends in Biochemical Sciences 21:468-471. (abstract).

Giordano, C., G. Stassi, R. De Maria, M. Todaro, P. Richiusa, G. Papoff, G. Ruberti, M. Bagnasco, R. Testi and A. Galluzzo. 1997. Potential involvement of Fas and its Ligand in the pathogenesis of Hashimoto's Thyroiditis. Science 275:960-963. (abstract).

De Luca, A., R. De Maria, A. Baldi, R. Trotta, F. Facchiano, A. Giordano, R. Testi and G. Condorelli. 1997. Fas-induced changes in cdc2 and cdk2 kinase activity are not sufficient for triggering apoptosis in HUT-78 cells. Journal of Cell Biochemistry 64: 579-585.(abstract).

De Maria, R., L. Lenti, F. Malisan, F. d'Agostino, B. Tomassini, A. Zeuner, M.R. Rippo and R. Testi. 1997. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 277:1652-1655.(abstract).

Stassi, G., R. De Maria, G. Trucco, W. Rudert, R. Testi, A. Galluzzo, C. Giordano and M. Trucco. 1997. Nitric oxide primes pancreatic beta cells for fas-mediated destruction in insulin-dependent diabetes mellitus. Journal of Experimental Medicine 186:1193-1200.(abstract).

Signore, A., A. Annovazzi, E. Procaccini, P.E. Beales, J. Spencer, R. Testi and G. Ruberti. 1997. CD95 And CD95-Ligand Expression In Endocrine Pancreas Of NOD, NOR And Balb/c Mice. Diabetologia 40:1476-1479.(abstract)

De Maria, R., M.R. Rippo, E.H. Schuchman, and R. Testi. 1998. Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells. Journal of Experimental Medicine 187: 897-902 (abstract).

Stokes, T.A., M. Rymaszewski, P. L. Arscott, S. H. Wang, J. D. Bretz, J. Bartron, J. R. Baker Jr., P. Fiedler, C. E. Schaetzlein, H. Eibel, G. Papoff, G. Stassi, R. De Maria, C. Giordano, A. Galluzzo, M. Bagnasco, G. Ruberti, and R. Testi. 1998. Constitutive Expression of FasL in Thyrocytes. Science 279:2015a (Technical Comment)

De Maria, R. and R. Testi. 1998. Fas-FasL interactions: a common pathogenetic mechanism in organ-specific autoimmunity. Immunology Today 19:121-125 (abstract)

Nervi, C., F.F. Ferrara, M. Fanelli, M.R. Rippo, B. Tomassini, P.F. Ferrucci, M. Ruthardt, V. Gelmetti, D. Diverio, C. Gambacorti, F. Grignani, P.G. Pelicci and R. Testi. 1998. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion product. Blood 92:2244-2251.(abstract)

Stassi, G., M. Todaro, F. Bucchieri, A. Stoppacciaro, F. Farina, G. Zummo, R. Testi, and R. De Maria. 1999. Fas/Fas Ligand-Driven T Cell Apoptosis as a Consequence of Ineffective Thyroid Immunoprivilege in Hashimoto's Thyroiditis. Journal of Immunology 162:263-267. (abstract)

Malisan F. and R. Testi. 1999. Lipid signaling in CD95-mediated apoptosis. FEBS Lett. 452:100-103. (abstract)

Procyk, K. J., M. R. Rippo, R. Testi, F. Hoffmann, P. J. Parker and M. Baccarini. 1999. Distinct mechanisms target SEK1 and JNK during infection of macrophages with Salmonella. Journal of Immunology 163:4924-4930. (abstract)

Aquaro S, S. Panti, MC Caroleo, E. Balestra, A. Cenci, F. Forbici, G. Ippolito, A. Mastino, R. Testi, V. Mollace, R. Calio and CF Perno. 2000. Primary macrophages infected by human immunodeficiency virus trigger CD95-mediated apoptosis of uninfected astrocytes. J Leukoc Biol. 68:429-435.

Procyk K. J., M. R. Rippo, R. Testi, F. Hofmann, P. J. Parker, and M. Baccarini. 2000. Lipopolysaccharide induces Jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C and phosphatidylcholine-dependent phospholipase C. Blood 96: 2592-2598. (abstract)

Rippo M.R., F. Malisan, L. Ravagnan, B. Tomassini, I. Condo', P. Costantini, S. A. Susin, A. Rufini, M. Todaro, G. Kroemer and R. Testi. 2000. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion. FASEB J. 14:2047-2054. (abstract)