Meetings 1999

Microbial escape mechanisms and new therapies of AIDS and tuberculosis.

Jolly Grande Albergo delle Terme, Ischia, April 18-19, 1999

Programme:

MICROBIAL ESCAPE MECHANISMS AND NEW THERAPIES OF AIDS AND TUBERCULOSIS
(April 18-19, 1999)

Jolly Grande Albergo delle Terme
Via A. De Luca, 42- 80077 Ischia, Italy (tel. 39.081.99174)

AIDS and Emerging Infections in the Mediterranean Area
L. Montagnier and G. Ippolito

9.00 L. Montagnier (Paris): Introduction
9.15 G. Ippolito and N. Petrosillo (Rome): Migration and Infectious Diseases in the Mediterranean Area: An Overview

HIV-1 Nef protein and disease progression
L. Montagnier and V.Erfle

9.30 V. Erfle (Neuherberg): HIV - Nef as a factor of cell activation
9.50 E.Vicenzi (Milan) Defective nef alleles in a cohort of haemophiliacs with progressing and non progressing HIV infection.
10.10 M. Federico (Rome): The expression of a natural-occurring HIV-1 nef allele potently inhibits the HIV replication: studies on the mechanism of action and perspectives in gene therapy.
10.20 C .Montesano (Rome): HIV-1 Nef interferes with antigen-specific proliferation of Antigen-specific T helper cell lines.
10.40 U.Visco Comandini (Rome): HIV-1 nef mutations and clinical long-term non progression: a molecular epidemiology study.

11.00 Coffee Break

HLA and HIV -1 pathogenesis
M.Lopez-Bótet, A.Moretta and A.Dalgleish

11.10 A. Dalgleish (London): HIV & HLA; association et molecular and clinical levels
11.30 A. Moretta (Genoa): HLA-specific and non HLA-specific NK receptors
11.50 M. López-Botet (Madrid): NK Cell-Mediated Recognition of HLA-E and HLA-G Class Ib molecule.
12.10 F.Poccia (Rome): HLA - E influence on antiviral cytotoxic activity and HIV -1 pathogenesis
12.30 A Beretta (Paris): To be communicated

13.00 Lunch

Antiviral and cytokine - based therapies
A.Cassone and M.L. Gougeon

15.00 A.Cassone (Rome): Non Antiviral Activities of HIV-Protease Inhibitors.
15.20 M. L. Gougeon (Paris): Accumulation of TNFa-Producing T Cells as a Consequence of Defective Regulation by Apoptosis During HAART. Relation with the Lipodystrophy Syndrome.
15.40 G. D'Offizi (Rome): Cytokine - treatments reduce spontaneous apoptosis in HIV infected patients undergoing HAART.
16.00 C.F Perno (Rome): Nerve Growth factor is an autocrine factor essential for the survival of macrophages infected by human immunodeficiency virus.

16.20 Coffee Break

Immunophathogenesis of AIDS and protective immunity
S.Romagnani and G. Poli

16.30 S. Romagnani (Florence): Th1/ Th2 responses, HIV coreceptors and HIV expression.
16.50 G.Poli (Milan): Selective Replication of R5, but not X4 HIV Strains in TH1, TH0, and TH2 lymphocytes.
17.10 L.Imberti (Brescia): Depleted CD4 compartments are refilled by CD8+CD28-CD11b lymphocytes.
17.30 M. Wallace (Madison): Lymphocyte Activation during acute SHIV89.6PD Infection in Macaques.
17.50 M. Salvato (Madison): High fasL predisposes rhesus macaques to rapid AIDS progression"
18.10 J.L. Heeney ( Rijswijk): Protective immunity to HIV Infection and AIDS
18.30 R. Gluck (Berne): Development of HIV vaccine which protects on the humoral and mucosal level

20.0 Dinner

9.00 M. Bonneville (Nantes): Identification of a novel human gd T cell subset reactive against (A) conserved antigen (S) possibly shared by B cell tumours and bacteria.
9.20 J.J. Fournié (Tolouse): To be comunicated
9.40 M.Mattei (Rome): Nonpeptidic Phosphoantigens elicit delayed - type hypersensitivity and antimycobacterial T cell response in non-human primates.
10.00 M.Malkovsky (Madison): Activities of gamma/delta T -cells in vitro and in vivo: a basis for novel vaccines.
10.20 F.Martini (Rome): gd T anergy in HIV-infected persons with opportunistic infections and recovery after highly active antiretroviral therapy.
10.40 C.D. Pauza (Madison): Changes on the gamma/delta T-cell repertoire after HIV-1 infection and therapy.

11.00 Coffee Break

MHC-unrestricted T cells in pathogenesis and therapy
G.De Libero and P. Fisch

11.10 G.De Libero (Basel): Recognition of self glycolipids by human autoreactive T cells.
11.30 L.Battistini (Rome): Interleukin-12 mediated NKRP1A upregulation and consequent enhancement of endothelial transmigration of Vd2+ TCRgd+ T lymphocytes from healthy donors and multiple sclerosis patients.
11.50 P.Fisch (Freiburg): Inhibitory MHC class I receptors on human gd T cells in tumour immunity and autoimmunity.
12. 10 S.Abrignani ( Siena): Life, activation and death of intra-hepatic T lymphocytes.
12.30 G. Antonelli (Rome): Predictive Markers of therapeutic response to interferon a in chronic active hepatitis C patients.

13.00 Lunch

Genetic factors and immunological parameters of tuberculosis
V. Colizzi, C.Saltini and A.Sanduzzi

15.00 C. Saltini (Modena): Genetic factors in Lung Granuloma formation: role of the natural resistance-associated macrophage protein 1 (NRAMP1) gene in Sarcoidosis and in Berylliosis.
15.20 F. Mariani (Rome): Mycobacterium tuberculosis gene expression: different patterns of gene transcription are displayed in synthetic medium, in vitro infected human macrophages and TBC patients alveolar macrophages.
15.40 F. Dieli (Palermo): ab and gd T cell in responses in childhood tuberculosis.
16.00 F.Perna (Naples): Immunological evaluation of tubercular patients and their contacts.
16.20 M. Fraziano (Rome): Expression of CCR5 is Increased in Human Monocyte Derived- and in Alveolar- Macrophages in the Course of in vivo and in vitro Mycobacterium tuberculosis infection
16.40 M.L. Bocchino (Paris): Analysis at the single cell level of cytokine and chemokine expression by CD64⁺ monocytes in response to M.tuberculosis and modulation by IFN-g, IL-10 and IL-15. Consequences on AIDS pathogenesis

17.00 Coffee Break

17.10 M.Amicosante (Rome): Human monocytes lose surface CD14 expression in the course of apoptosis induced with high doses of Mycobacterium tuberculosis
17.30 A. Amendola (Rome): Inhibition of "tissue" Transglutaminase Increases Cell Survaival by Preventing Apoptosis.
17.50 G.Mancino (Rome): P2X₇ purinergic receptors and extracellular ATP promote the apoptosis-mediated killing of human monocytes/macrophages infected with Mycobacterium tuberculosis reducing the intracellular bacterial viability.
18.10 G. Anzalone (Prato): Serology of Tuberculosis: State of the ART

A.O. "V. MONALDI"
Via L.Bianchi, 80131 Naples, Italy